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This book describes essential principles of and approaches to monitoring and modeling algal blooms. Freshwater algal blooms have become a growing concern worldwide. They are caused by a high level of cyanobacteria, particularly Microcystis spp. and Cylindrospermopsis raciborskii, which can produce microcystin and cylindrospermopsin, respectively. Since long-term exposure to these cyanotoxins may affect public health, the reliable detection and quantification of these harmful algae species has become a priority in water quality management. The book utilizes an advanced monitoring approach to identify and quantify cyanobacteria species and various cyanotoxin-producing genotypes. Further, it uses a modeling approach to forecast the occurrence of the phytoplankton that causes algal blooms in freshwater reservoirs, providing a comprehensive picture of currently available micro- and macro-techniques for studying the problem of algal blooms. As such, it offers a valuable guide for researchers, graduate students and professional engineers engaged in monitoring and modeling water quality in lakes and reservoirs. Dr. InChio Lou is an Assistant Professor at University of Macau, Macau, China. Dr. Boping Han is a professor at Jinan Universtiy, Guangzhou, China. Weiying Zhang is a researcher of Environmental Engineering in the area of freshwater phytoplankton at University of Macau, Macau, China.
Systemic corticosteroids play an integral role in the management of many inflammatory and immunologic conditions, but these agents are also associated with serious risks. Osteoporosis, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, Cushing's syndrome, psychiatric disturbances and immunosuppression are among the more serious side effects noted with systemic corticosteroid therapy, particularly when used at high doses for prolonged periods. This comprehensive article reviews these adverse events and provides practical recommendations for their prevention and management based on both current literature and the clinical experience of the authors. Proceeds from the sale of this book go to the support of an elderly disabled person.
There has been substantial growth in the use of data monitoring committees in recent years, by both government agencies and the pharmaceutical industry. This growth has been brought about by increasing recognition of the value of such committees in safeguarding trial participants as well as protecting trial integrity and the validity of conclusions. This very timely book describes the operation of data monitoring committees, and provides an authoritative guide to their establishment, purpose and responsibilities.<br> * Provides a practical overview of data monitoring in clinical trials.<br> * Describes the purpose, responsibilities and operation of data monitoring committees.<br> * Provides directly applicable advice for those managing and conducting clinical trials, and those serving on data monitoring committees.<br> * Gives insight into clinical data monitoring to those sitting on regulatory and ethical committees.<br> * Discusses issues pertinent to those working in clinical trials in both the US and Europe.<br> The practical guidance provided by this book will be of use to professionals working in and/or managing clinical trials, in academic, government and industry settings, particularly medical statisticians, clinicians, trial co-ordinators, and those working in regulatory affairs and bioethics.
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